Neural Plasticity Lab

Plasticity / Learning

Plasticity is the ability of the brain to adapt to new experiences and boundary conditions over the entire lifespan. When we learn something, we acquire knowledge and skills through instruction, practice and experience. This learning requires permanent changes in the brain. The ability of the brain to change through learning is called neuroplasticity.

Aging

The age structure of modern industrial societies is characterized by an enormous increase of the elderly. Thus, the understanding of the aging process is increasingly of great importance. The aim is to create foundations for healthy aging, which makes it possible to live independently as long as possible.

Haptic

The sense of touch - The underrated sense. How important is the sense of touch in a predominantly visually dominated world? What distinguishes the sense of touch from other senses? We investigate the properties and characteristics of tactile perception in the context of neural processing and "haptic design".

Special: Stroke rehabilitation

As part of a collaboration between neuroscientists of the “Institute for Neuroinformatics” and neurologists of the hospital “Bergmannsheil”, both in Bochum, a method for performance improvement of the human sense of touch has been developed in recent years: The sensitive stimulation.

Sensory stimulation glove

Selective electrical stimulation protocols can stimulate learning processes associated with improved tactile performance. To ease up the sensory stimulation to the subject, specific stimulation gloves were developed. These allow specific stimulation of all five fingers of one hand. This study will investigate whether the known influence of stimulation protocols can be observed on the tactile performance of the finger by stimulation gloves.

Dinse, H. R., & Tegenthoff, M. (2015). Evoking plasticity through sensory stimulation: Implications for learning and rehabilitation . e-Neuroforum, 1(1), .
Haag, L. M., Heba, S., Lenz, M., Glaubitz, B., Höffken, O., Kalisch, T., et al. (2015). Resting BOLD fluctuations in the primary somatosensory cortex correlate with tactile acuity. Cortex, 64, 20–28.
Ritter, P., Born, J., Brecht, M., Dinse, H. R., Heinemann, U., Pleger, B., et al. (2015). State-dependencies of learning across brain scales. Frontiers in Computational Neuroscience, 9.
Muret, D., Dinse, H. R., Macchione, S., Urquizar, C., Farne, A., & Reilly, K. T. (2014). Touch improvement at the hand transfers to the face. Curr. Biol., 24(16), R736–737.
Bruns, P., Camargo, C. J., Campanella, H., Esteve, J., Dinse, H. R., & Röder, B. (2014). Tactile Acuity Charts: A Reliable Measure of Spatial Acuity. PloS one, 9(2), e87384.
Kattenstroth, J. C., Kalisch, T., Tegenthoff, M., & Dinse, H. R.. (2014). Tanz im Alter: Fitness für Gehirn, Geist und Körper . In C. Behrens & Rosenberg, C. (Eds.), TanzZeit – LebensZeit, Tanzforschung 2014 (pp. 115–135). Leipzig: Henschel Verlag .
Ladda, A. M., Pfannmoeller, J. P., Kalisch, T., Roschka, S., Platz, T., Dinse, H. R., & Lotze, M. (2014). Effects of combining 2 weeks of passive sensory stimulation with active hand motor training in healthy adults. PloS one, 9(1), e84402.
Lissek, S., Vallana, G. S., Schlaffke, L., Lenz, M., Dinse, H. R., & Tegenthoff, M. (2014). Opposing effects of dopamine antagonism in a motor sequence task—tiapride increases cortical excitability and impairs motor learning. Frontiers in behavioral neuroscience, 8.
Sczesny-Kaiser, M., Bauknecht, A., Höffken, O., Tegenthoff, M., Dinse, H. R., Jancke, D., et al. (2014). Synergistic effects of noradrenergic modulation with atomoxetine and 10 Hz repetitive transcranial magnetic stimulation on motor learning in healthy humans. BMC neuroscience, 15(1), 46.
Sczesny-Kaiser, M., Bauknecht, A., Hoffken, O., Tegenthoff, M., Dinse, H. R., Jancke, D., et al. (2014). Synergistic effects of noradrenergic modulation with atomoxetine and 10 Hz repetitive transcranial magnetic stimulation on motor learning in healthy humans. BMC Neurosci, 15, 46.
Sigala, R., Haufe, S., Roy, D., Dinse, H. R., & Ritter, P. (2014). The role of alpha-rhythm states in perceptual learning: insights from experiments and computational models. Front Comput Neurosci, 8, 36.
Kattenstroth, J. C., Kalisch, T., Kowalewski, R., Tegenthoff, M., & Dinse, H. R.. (2013). Quantitative assessment of joint position sense recovery in subacute stroke patients: a pilot study. J Rehabil Med, 45(10), 1004–1009.
Hickmott, P., & Dinse, H.. (2013). Effects of aging on properties of the local circuit in rat primary somatosensory cortex (S1) in vitro. Cereb. Cortex, 23(10), 2500–2513.
Hickmott, P., & Dinse, H.. (2013). Effects of aging on properties of the local circuit in rat primary somatosensory cortex (S1) in vitro. Cereb. Cortex, 23(10), 2500–2513.
Beste, C., & Dinse, H. R.. (2013). Learning without training. Curr. Biol., 23(11), R489–499.
Gatica Tossi, M. A., Lillemeier, A. S., & Dinse, H. R.. (2013). Influence of stimulation intensity on paired-pulse suppression of human median nerve somatosensory evoked potentials. Neuroreport, 24(9), 451–456.
Hoffken, O., Lenz, M., Sczesny-Kaiser, M., Dinse, H. R., & Tegenthoff, M. (2013). Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials. Brain Stimul, 6(2), 118–121.
Freyer, F., Becker, R., Dinse, H. R., & Ritter, P. (2013). State-dependent perceptual learning. J. Neurosci., 33(7), 2900–2907.
Kattenstroth, J. C., Kalisch, T., Holt, S., Tegenthoff, M., & Dinse, H. R.. (2013). Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardio-respiratory functions. Front Aging Neurosci, 5, 5.
Lissek, S., Vallana, G. S., Gunturkun, O., Dinse, H., & Tegenthoff, M. (2013). Brain activation in motor sequence learning is related to the level of native cortical excitability. PLoS ONE, 8(4), e61863.
Tossi, G., Stude, P., Schwenkreis, P., Tegenthoff, M., & Dinse, H. R.. (2013). Behavioural and neurophysiological markers reveal differential sensitivity to homeostatic interactions between centrally and peripherally applied passive stimulation. European Journal of Neuroscience, 38(6), 2893–2901.
Beste, C., Wascher, E., Dinse, H. R., & Saft, C. (2012). Faster perceptual learning through excitotoxic neurodegeneration. Curr. Biol., 22(20), 1914–1917.
Schlieper, S., & Dinse, H. R.. (2012). Perceptual improvement following repetitive sensory stimulation depends monotonically on stimulation intensity. Brain Stimul, 5(4), 647–651.
Hoffken, O., Lenz, M., Hockelmann, N., Dinse, H. R., & Tegenthoff, M. (2012). Noradrenergic modulation of human visual cortex excitability assessed by paired-pulse visual-evoked potentials. Neuroreport, 23(12), 707–711.
Dinse, H. R. (2012). Choosing to improve or to impair. Clin Neurophysiol, 123(6), 1063–1064.
Lenz, M., Tegenthoff, M., Kohlhaas, K., Stude, P., Hoffken, O., Gatica Tossi, M. A., et al. (2012). Increased excitability of somatosensory cortex in aged humans is associated with impaired tactile acuity. J. Neurosci., 32(5), 1811–1816.
Wilimzig, C., Ragert, P., & Dinse, H. R.. (2012). Cortical topography of intracortical inhibition influences the speed of decision making. Proc. Natl. Acad. Sci. U.S.A., 109(8), 3107–3112.
Canu, M. H., Coq, J. O., Barbe, M. F., & Dinse, H. R.. (2012). Plasticity of adult sensorimotor system. Neural Plast., 2012, 768259.
Freyer, F., Reinacher, M., Nolte, G., Dinse, H. R., & Ritter, P. (2012). Repetitive tactile stimulation changes resting-state functional connectivity-implications for treatment of sensorimotor decline. Front Hum Neurosci, 6, 144.
Kalisch, T., Kattenstroth, J. C., Kowalewski, R., Tegenthoff, M., & Dinse, H. R.. (2012). Age-related changes in the joint position sense of the human hand. Clin Interv Aging, 7, 499–507.
Kalisch, T., Kattenstroth, J. C., Kowalewski, R., Tegenthoff, M., & Dinse, H. R.. (2012). Cognitive and tactile factors affecting human haptic performance in later life. PLoS ONE, 7(1), e30420.
Kattenstroth, J. C., Kalisch, T., Peters, S., Tegenthoff, M., & Dinse, H. R.. (2012). Long-term sensory stimulation therapy improves hand function and restores cortical responsiveness in patients with chronic cerebral lesions. Three single case studies. Front Hum Neurosci, 6, 244.
Kowalewski, R., Kattenstroth, J. C., Kalisch, T., & Dinse, H. R.. (2012). Improved acuity and dexterity but unchanged touch and pain thresholds following repetitive sensory stimulation of the fingers. Neural Plast., 2012, 974504.
Heinisch, C., Dinse, H. R., Tegenthoff, M., Juckel, G., & Brune, M. (2011). An rTMS study into self-face recognition using video-morphing technique. Soc Cogn Affect Neurosci, 6(4), 442–449.
Beste, C., Wascher, E., Gunturkun, O., & Dinse, H. R.. (2011). Improvement and impairment of visually guided behavior through LTP- and LTD-like exposure-based visual learning. Curr. Biol., 21(10), 876–882.
Dinse, H. R. (2011). Brain Plasticity and Touch . In M. J. Hertenstein & Weiss, S. J. (Eds.), The Handbook of Touch: neuroscience, behavioral, and health perspectives (pp. 85–120). New York : Springer .
Dinse, H. R., Kattenstroth, J. C., Gatica Tossi, M. A., Tegenthoff, M., & Kalisch, T. (2011). Sensory stimulation for augmenting perception, sensorimotor behaviour and cognition . In H. Markram & Segev, I. (Eds.), Augmenting Cognition (pp. 11–39). Lausanne : EPFL Press .
Dinse, H. R., Kattenstroth, J. C., Tegenthoff, M., & Kalisch, T. (2011). Plastizität, motorisches Lernen und sensible Stimulation . In C. Dettmers & Stephan, K. M. (Eds.), Motorische Therapie nach Schlaganfall (pp. 17–43). : Hippocampus .
Geissler, M., Dinse, H. R., Neuhoff, S., Kreikemeier, K., & Meier, C. (2011). Human umbilical cord blood cells restore brain damage induced changes in rat somatosensory cortex. PLoS ONE, 6(6), e20194.
Gopinath, K., Ringe, W., Goyal, A., Carter, K., Dinse, H. R., Haley, R., & Briggs, R. (2011). Striatal functional connectivity networks are modulated by fMRI resting state conditions. Neuroimage, 54(1), 380–388.
Kalisch, T., Kattenstroth, J. C., Noth, S., Tegenthoff, M., & Dinse, H. R.. (2011). Rapid assessment of age-related differences in standing balance. J Aging Res, 2011, 160490.
Kalisch, T., Richter, J., Lenz, M., Kattenstroth, J. C., Kolankowska, I., Tegenthoff, M., & Dinse, H. R.. (2011). Questionnaire-based evaluation of everyday competence in older adults. Clin Interv Aging, 6, 37–46.
Kattenstroth, J. C., Kalisch, T., Kolankowska, I., & Dinse, H. R.. (2011). Balance, sensorimotor, and cognitive performance in long-year expert senior ballroom dancers. J Aging Res, 2011, 176709.
David-Jurgens, M., & Dinse, H. R.. (2010). Effects of aging on paired-pulse behavior of rat somatosensory cortical neurons. Cereb. Cortex, 20(5), 1208–1216.
Kalisch, T., Tegenthoff, M., & Dinse, H. R.. (2010). Repetitive electric stimulation elicits enduring improvement of sensorimotor performance in seniors. Neural Plast., 2010, 690531.
Kattenstroth, J. C., Kolankowska, I., Kalisch, T., & Dinse, H. R.. (2010). Superior sensory, motor, and cognitive performance in elderly individuals with multi-year dancing activities. Front Aging Neurosci, 2, .
Leonhardt, R., & Dinse, H. R.. (2009). Receptive field plasticity of area 17 visual cortical neurons of adult rats. Exp Brain Res, 199(3-4), 401–410.
Smith, P. S., Dinse, H. R., Kalisch, T., Johnson, M., & Walker-Batson, D. (2009). Effects of repetitive electrical stimulation to treat sensory loss in persons poststroke. Arch Phys Med Rehabil, 90(12), 2108–2111.
Hoffken, O., Stude, P., Lenz, M., Bach, M., Dinse, H. R., & Tegenthoff, M. (2009). Visual paired-pulse stimulation reveals enhanced visual cortex excitability in migraineurs. Eur. J. Neurosci., 30(4), 714–720.
Kalisch, T., Ragert, P., Schwenkreis, P., Dinse, H. R., & Tegenthoff, M. (2009). Impaired tactile acuity in old age is accompanied by enlarged hand representations in somatosensory cortex. Cereb. Cortex, 19(7), 1530–1538.
Lissek, S., Wilimzig, C., Stude, P., Pleger, B., Kalisch, T., Maier, C., et al. (2009). Immobilization impairs tactile perception and shrinks somatosensory cortical maps. Curr. Biol., 19(10), 837–842.
Dinse, H. R. (2009). Gehirne begreifen und erfassen: Tasten – der unterschätzte Sinn . In R. Rosenzweig (Ed.), Nicht wahr?! - Sinneskanäle, Hirnwindungen und Grenzen der Wahrnehmung (pp. 133–164). : mentis Verlag .
Dinse, H. R., Tegenthoff, M., Heinisch, C., & Kalisch, T. (2009). Ageing and Touch . In B. Goldstein (Ed.), The Sage Encyclopedia of Perception (pp. 21–24). : Sage .
Langner, G., Dinse, H. R., & Godde, B. (2009). A map of periodicity orthogonal to frequency representation in the cat auditory cortex. Front Integr Neurosci, 3, 27.
Benali, A., Weiler, E., Benali, Y., Dinse, H. R., & Eysel, U. T. (2008). Excitation and inhibition jointly regulate cortical reorganization in adult rats. J. Neurosci., 28(47), 12284–12293.
Bliem, B., Muller-Dahlhaus, J. F., Dinse, H. R., & Ziemann, U. (2008). Homeostatic metaplasticity in the human somatosensory cortex. J Cogn Neurosci, 20(8), 1517–1528.
Hoffken, O., Grehl, T., Dinse, H. R., Tegenthoff, M., & Bach, M. (2008). Paired-pulse behavior of visually evoked potentials recorded in human visual cortex using patterned paired-pulse stimulation. Exp Brain Res, 188(3), 427–435.
David-Jurgens, M., Churs, L., Berkefeld, T., Zepka, R. F., & Dinse, H. R.. (2008). Differential effects of aging on fore- and hindpaw maps of rat somatosensory cortex. PLoS ONE, 3(10), e3399.
Dinse, H. R. (2008). Haptic Banknote Design . In M. Grunwald (Ed.), Human Haptic Perception - Basics and Applications (pp. 537–547). : Birkhäuser .
Dinse, H. R., Wilimzig, C., & Kalisch, T. (2008). Learning in Haptic Perception . In M. Grunwald (Ed.), Human Haptic Perception - Basics and Applications (pp. 165–182). : Birkhäuser .
Kalisch, T., Tegenthoff, M., & Dinse, H. R.. (2008). Improvement of sensorimotor functions in old age by passive sensory stimulation. Clin Interv Aging, 3(4), 673–690.
Ragert, P., Franzkowiak, S., Schwenkreis, P., Tegenthoff, M., & Dinse, H. R.. (2008). Improvement of tactile perception and enhancement of cortical excitability through intermittent theta burst rTMS over human primary somatosensory cortex. Exp Brain Res, 184(1), 1–11.
Ragert, P., Kalisch, T., Bliem, B., Franzkowiak, S., & Dinse, H. R.. (2008). Differential effects of tactile high- and low-frequency stimulation on tactile discrimination in human subjects. BMC Neurosci, 9, 9.
Schwenkreis, P., El Tom, S., Ragert, P., Pleger, B., Tegenthoff, M., & Dinse, H. R.. (2007). Assessment of sensorimotor cortical representation asymmetries and motor skills in violin players. Eur. J. Neurosci., 26(11), 3291–3302.
Hoffken, O., Veit, M., Knossalla, F., Lissek, S., Bliem, B., Ragert, P., et al. (2007). Sustained increase of somatosensory cortex excitability by tactile coactivation studied by paired median nerve stimulation in humans correlates with perceptual gain. J. Physiol. (Lond.), 584(Pt 2), 463–471.
Bliem, B., Frombach, E., Ragert, P., Knossalla, F., Woitalla, D., Tegenthoff, M., & Dinse, H. R.. (2007). Dopaminergic influences on changes in human tactile acuity induced by tactile coactivation. Exp Brain Res, 181(1), 131–137.
McNamara, A., Tegenthoff, M., Dinse, H., Buchel, C., Binkofski, F., & Ragert, P. (2007). Increased functional connectivity is crucial for learning novel muscle synergies. Neuroimage, 35(3), 1211–1218.
Seitz, A. R., & Dinse, H. R.. (2007). A common framework for perceptual learning. Curr. Opin. Neurobiol., 17(2), 148–153.
Dinse, H. R., Ragert, P., & Tegenthoff, M. (2007). Somatosensorik . In H. Siebner & Ziemann, U. (Eds.), Das TMS-Buch. Transkranielle Magnetstimulation (pp. 439–448). Heidelberg : Springer .
Kalisch, T., Tegenthoff, M., & Dinse, H. R.. (2007). Differential effects of synchronous and asynchronous multifinger coactivation on human tactile performance. BMC Neurosci, 8, 58.
Pleger, B., Ragert, P., Schwenkreis, P., Forster, A. F., Wilimzig, C., Dinse, H., et al. (2006). Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome. Neuroimage, 32(2), 503–510.
Dinse, H. R., Kleibel, N., Kalisch, T., Ragert, P., Wilimzig, C., & Tegenthoff, M. (2006). Tactile coactivation resets age-related decline of human tactile discrimination. Ann. Neurol., 60(1), 88–94.
Meier, C., Middelanis, J., Wasielewski, B., Neuhoff, S., Roth-Haerer, A., Gantert, M., et al. (2006). Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Pediatr. Res., 59(2), 244–249.
Dinse, H. R. (2006). Cortical reorganization in the aging brain. Prog. Brain Res., 157, 57–80.
Kalisch, T., Wilimzig, C., Kleibel, N., Tegenthoff, M., & Dinse, H. R.. (2006). Age-related attenuation of dominant hand superiority. PLoS ONE, 1, e90.
Tegenthoff, M., Ragert, P., Pleger, B., Schwenkreis, P., Forster, A. F., Nicolas, V., & Dinse, H. R.. (2005). Improvement of tactile discrimination performance and enlargement of cortical somatosensory maps after 5 Hz rTMS. PLoS Biol., 3(11), e362.
Jancke, D., Erlhagen, W., Schöner, G., & Dinse, H. R.. (2004). Shorter latencies for motion trajectories than for flashes in population responses of cat primary visual cortex. The Journal of Physiology, 556(3), 971–982.
Ragert, P., Schmidt, A., Altenmuller, E., & Dinse, H. R.. (2004). Superior tactile performance and learning in professional pianists: evidence for meta-plasticity in musicians. Eur. J. Neurosci., 19(2), 473–478.
Pleger, B., Foerster, A. F., Ragert, P., Dinse, H. R., Schwenkreis, P., Malin, J. P., et al. (2003). Functional imaging of perceptual learning in human primary and secondary somatosensory cortex. Neuron, 40(3), 643–653.
Dinse, H. R., Ragert, P., Pleger, B., Schwenkreis, P., & Tegenthoff, M. (2003). Pharmacological modulation of perceptual learning and associated cortical reorganization. Science, 301(5629), 91–94.
Godde, B., Berkefeld, T., David-Jurgens, M., & Dinse, H. R.. (2002). Age-related changes in primary somatosensory cortex of rats: evidence for parallel degenerative and plastic-adaptive processes. Neurosci Biobehav Rev, 26(7), 743–752.
Li, S. C., & Dinse, H. R.. (2002). Aging of the brain, sensorimotor, and cognitive processes. Neurosci Biobehav Rev, 26(7), 729–732.
Godde, B., Leonhardt, R., Cords, S. M., & Dinse, H. R.. (2002). Plasticity of orientation preference maps in the visual cortex of adult cats. Proc. Natl. Acad. Sci. U.S.A., 99(9), 6352–6357.
Dinse, H. R., & Böhmer, G. (2002). Plastic-adaptive properties of cortical areas . In A. Schüz & Miller, R. (Eds.), Cortical Areas: Unity and Diversity: Conceptual Advances in Brain Research (pp. 311–348). London : Taylor & Francis .
Dinse, H. R., & Merzenich, M. M. (2002). Adaptation of Inputs in the Somatosensory System . In M. Fahle & Poggio, T. (Eds.), Perceptual Learning (pp. 19–42). : MIT Press .
Dinse, H. R., & Schreiner, C. E. (2002). Do primary sensory areas play homologous roles in different sensory modalities? . In A. Schüz & Miller, R. (Eds.), Cortical Areas: Unity and Diversity: Conceptual Advances in Brain Research (pp. 273–310). London : Taylor & Francis .
Pleger, B., Dinse, H. R., Ragert, P., Schwenkreis, P., Malin, J. P., & Tegenthoff, M. (2001). Shifts in cortical representations predict human discrimination improvement. Proc. Natl. Acad. Sci. U.S.A., 98(21), 12255–12260.
Dinse, H. R., & Jancke, D.. (2001). Chapter 10: Comparative population analysis of cortical representations in parametric spaces of visual field and skin : a unifying role for nonlinear interactions as a basis for active information processing across modalities. In M. A. L. Nicolelis (Ed.), Advances in neural population coding (pp. 155–173). Elsevier.
Dinse, H. R., & Jancke, D.. (2001). Comparative population analysis of cortical representations in parametric spaces of visual field and skin: A unifying role for nonlinear interactions as a basis for active information processing across modalities. Progress in brain research, 130, 155–173.
Dinse, H. R., & Jancke, D.. (2001). Time-variant processing in V1: From microscopic (single cell) to mesoscopic (population) levels. Trends in neurosciences, 24(4), 203–205.
Jancke, D., Erlhagen, W., Dinse, H. R., Akhavan, A. C., Giese, M., Steinhage, A., & Schöner, G.. (1999). Parametric population representation of retinal location: Neuronal interaction dynamics in cat primary visual cortex. J Neurosci, 19(20), 9016–9028.